A Paradox: the roles of inositolphosphoglycans in mediating insulin sensitivity and hyperandrogenism in the polycystic ovary syndrome.
نویسندگان
چکیده
Current evidence suggests that insulin resistance contributes to the pathophysiologic features of the polycystic ovary syndrome (PCOS). The observation that insulin resistance is a central feature of PCOS leads to studies of the insulin signaling system in this disorder. This article reviews the possible role of putative insulin mediators, inositolphosphoglycans (IPG) mediators, in PCOS. We will focus on how IPGs mediate (a) hyperandrogenism and (b) insulin sensitivity in this disorder.
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عنوان ژورنال:
- Hormones
دوره 3 4 شماره
صفحات -
تاریخ انتشار 2004